MBL2 and hyperinsulinemic hypoglycemia, familial, 4: It is theoretically possible that MBL-deficient individuals are at significant risk from premature death and this accounts for an overall lower frequency of genotypic deficiency in adults; however such an effect has not been demonstrated in a large population-based study of MBL deficiency [20] and furthermore in our study we did not observe an effect of age on MBL status during regression analysis.