Huang have reported that Cx43 may suppress glioma proliferation by dowregulation of monocyte chemotactic protein 1(MCP-1)[19], the inhibitory effect of bFGF siRNA on U251 cell proliferation is at least partially due to the increased expression of Cx43, which may affect expression of other growth factors, such as down regulating MCP-1. Here, CCL2 is linked to central nervous system cancer.