Despite the association of cytoplasmic myosin VI immunopositivity with lower Fuhrman grades, the mean survival times for subjects with cytoplasmic myosin VI immunopositive Fuhrman grade II tumours died of RCC during follow-up were shorter in comparison with subjects with cytoplasmic myosin VI immunonegative tumours. The gene discussed is MYO6; the disease is renal cell carcinoma.