In dogs, spontaneously occurring distinct genetic defects leading to dystrophin-deficient muscular dystrophy have been described in the Golden Retriever and German Short Haired Pointer [16], [17], [30], [31] Schatzberg et al. [16] described two male German Short Haired Pointer littermates with a large (>2.4 Mb) deletion of the p21 region of the X-chromosome that included the dystrophin gene and promoters. This evidence concerns the gene DMD and muscular dystrophy.