When tested jointly with four clinical covariates (hypercholesterolaemia, hypertension, smoking and sex), the effect of haplotype IL1-CCC on CAD was no longer significant in the whole sample (OR = 1.07, P = 0.57) nor in those affected by MI (OR = 1.26, P = 0.07), but it was nominally significant in younger cases (<50 years OR = 1.39, P = 0.05). Here, IL1B is linked to Hypercholesterolemia.