IGFBP3 and neoplasm: Interestingly, it was recently shown that IGFBP-3 inhibited cell migration, invasion, and metastasis in the human ovarian endometrioid carcinoma cell line OVRW59-P4 [51], an observation that correlates with the low levels of IGFBP-3 expression in high tumor grade, advanced stage, and poor survival in endometrioid carcinoma and EOC patients [50, 51].