Kaye et al. [51], Amler et al. [52], and Makhija et al. [53] in independent studies examined pertuzumab, a humanized recombinant monoclonal antibody that inhibits the dimerization of HER2 with EGFR, HER 3, and HER4, in patients with ovarian cancer. The gene discussed is EGFR; the disease is ovarian carcinoma.