Unlike endometrioid carcinomas, however, they lack expression of hormone receptors (estrogen receptor or progesterone receptor) [24], suggesting that the hormonal influence during oncogenesis is different; clear cell carcinomas may be analgous to the nonhormonally dependent Type 2 endometrial carcinomas while endometrioid carcinomas share many features (both morphological and molecular) with Type 1 carcinomas of the endometrium [25]. The gene discussed is ESR1; the disease is endometrioid adenocarcinoma.