TP53 and thyroid gland carcinoma: In a cohort of nearly 100 patients, Saltman et al. clearly demonstrated the presence of aberrant p53 expression in more aggressive phenotypes of thyroid carcinoma; the study demonstrated a gradual increase in p53 immunopositivity rate along the spectrum of thyroid carcinoma progression with a statistically significant difference between well-differentiated and anaplastic phenotypes (0% versus 31.8%, resp.; P < .001) [49].