Although the function of ROS in the activation of p38-MAPK (Yi et al, 2004; Lee et al, 2008; Chen et al, 2009), and the regulation of NF-κB activity (Hayakawa et al, 2003; Fujioka et al, 2004), has been characterised in substances-induced apoptosis in various cancer cells, the involvement of ROS in BD-induced pancreatic cancer cell apoptosis is yet to be elucidated. This evidence concerns the gene NFKB1 and cancer.