There is mounting evidence to suggest that constitutive activation of anti-apoptotic proteins, such as NF-κB (Aggarwal, 2000), signal transducers and activators of transcription proteins (Battle and Frank, 2002), heat shock proteins (Beere and Green, 2001) and phosphatidylinositide-3-kinase (Nicholson and Anderson, 2002) all have a function in the resistance of pancreatic cancer cells to apoptosis. The gene discussed is NFKB1; the disease is pancreatic neoplasm.