PPARG and Familial prostate cancer: Palakurthi et al (2001) have shown that TZD induces growth arrest by inhibition of translation initiation in PPARγ−/− embryonic stem cells. Furthermore, TZD analogues, which have a double bond adjoining the terminal TZD ring that is responsible for the abrogation of the PPARγ ligand property, retain the ability to induce apoptosis in prostate cancer cells (Weng et al, 2006).