CASP3 and neoplasm: With regard to apoptosis, at short-time observation (2 weeks), that is, in the presence of small-sized tumours, a low number of apoptotic cells was present, but in mice treated with RGZ, the number of cleaved caspase-3 immunopositive cells was higher than in controls, although the difference was not statistically significant (P=0.12) (Table 1 and Figure 3A).