EGFR and head and neck squamous cell carcinoma: These findings are in agreement with other trials, showing that the prevalence of EGFR amplification in SCCHN is low [57, 58] and that EGFR gene copy numbers are not correlated with tumor response in patients with recurrent/metastatic SCCHN, who nevertheless responded to the EGFR tyrosine kinase inhibitors (TKIs) erlotinib or gefitinib [59, 60].