Even though high EGFR protein expression has been reported to be predictive for increased tumor response in patients with SCCHN treated with conventional fractionated [9] or accelerated [53, 54] RT, this finding has not been confirmed in randomized studies in patients with recurrent and/or metastatic SCCHN treated with gefitinib [55] or cisplatin and cetuximab [56]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.