Two hundred and eleven patients with asymptomatic AS with a peak AS velocity of >2.5m/s (average peak AS velocity 3.96 m/s; mean AVA 0.84 cm2) were retrospectively identified and the rates of hemodynamic progression of AS were compared between patients who were taking an angiotensin converting enzyme inhibitor (ACEI) versus those who were not [29]. This evidence concerns the gene ACE and aortic valve stenosis.