In another prospective study of 3346 persons without heart failure, elevated BNP values above the 80th percentile (20 pg/mL for men and 23 pg/mL for women) were associated with multivariable-adjusted hazard ratios of 1.62 for death (P=0.02), 1.76 for a first major cardiovascular event (P=0.03), 1.91 for atrial fibrillation (P= 0.02), 1.99 for stroke or transient ischemic attack (P=0.02), and 3.07 for heart failure (P=0.002) [40]. This evidence concerns the gene NPPB and heart failure.