In fact, among plasma levels of ANP, BNP, cGMP, and norepinephrine and clinical and hemodynamic parameters, only high levels of plasma BNP (P<.0001) and pulmonary capillary wedge pressure (P=.003) were significant independent predictors of the mortality in patients with HF by Cox proportional hazard analysis [109]. Here, NPPB is linked to hydrops fetalis.