HP and diabetes mellitus: The marked increase in lipid peroxidation products of arachidonic acid in the myocardium of DM Hp 2 mice occurring after myocardial ischemia-reperfusion [95] prompted Levy and colleagues to investigate whether antioxidant therapy with vitamin E might have reduced cardiovascular events in Hp 2-2 DM patients that participated in the HOPE (Heart Outcomes Prevention Evaluation) trial (23).