TP53 and cancer: In these analyses, p53 mutation–negative cancer was associated with smoking history (ever vs. never; OR = 1.31; 95% CI, 1.03–1.67), current smoking (OR = 1.43; 95% CI, 1.06–1.93), and lifetime intake of grilled and smoked meat (OR = 1.61; 95% CI, 1.27–2.05).