This powerful inhibitory effect of pesticides on insulin action likely explains the common finding emerging from several independent cross-sectional studies reporting an association between type 2 diabetes and the body burdens of p,p′-DDE, oxychlordane, or trans-nonachlor (Lee et al. 2006; Rignell-Hydbom et al. 2007; Turyk et al. 2009). The gene discussed is INS; the disease is type 2 diabetes mellitus.