Although the role of some of these genetic variants in Omi/HtrA2 is still debated [29,30], a potential contribution of Omi/HtrA2 to PD pathogenesis is underscored by its presence in characteristic intraneuronal protein aggregates in PD that not only contain α-synuclein protein but also show a specific co-staining with Omi/HtrA2 not observed in other neurodegenerative disorders [9,31]. The gene discussed is HTRA2; the disease is Parkinson disease.