Because it seemed possible that dysregulation of any one of these proteins might result in increased ROS accumulation and/or unrepaired DNA damage and could feasibly promote oncogenesis, we examined their expression as well as the damage markers 8-OxoG, γ-H2AX and nitrotyrosine, in normal mammary tissue, BH, DCIS and IBC. This evidence concerns the gene H2AX and ductal breast carcinoma in situ.