Additionally, the combination of tumor infiltrating Foxp3+ cells and GrB+ activated CTL was associated with the survival of late stage patients: a higher number of Foxp3+ and GrB+ cells was associated with a longer OS and PFS compared to a lower number of Foxp3+ and GrB+ cells (P < 0.001, Fig 3B). The gene discussed is FOXP3; the disease is neoplasm.