ERBB2 and breast cancer: In addition, there are studies indicating that dynamic contrast-enhanced MRI help to predict prognostic factors and biological activity of breast cancer by revealing morphological features and enhancement parameters of the primary tumors, such as angiogenesis, degree of fibrosis [9], histological grade [10,11], negative expression of estrogen repeptor and progesterone receptor [11], vascular endothelial growth factor (VEGF) expression [9] or HER-2 overexpression [12].