In their first aggregate data meta-analysis of nine randomized controlled trials (RCTs) of anti-TNFα antibody therapies (infliximab and adalimumab) versus placebo in patients with rheumatoid arthritis, Bongartz et al. [3] found a significantly increased risk for malignancies in anti-TNFα versus placebo treated patients with a pooled odds ratio of 3.3 (95% CI: 1.2 to 9.1). This evidence concerns the gene TNF and rheumatoid arthritis.