Simultaneous portal, splenic and mesenteric vein thrombosis is a rare condition and may be associated with malignancy, surgery, portal hypertension, hyperhomocysteinemia, Behçet's disease, oral contraceptive use, factor V Leiden mutation, local inflammatory conditions and hematological hypercoagulable states such as paroxysmal nocturnal hemoglobinuria and myeloproliferative disorders [4-6]. The gene discussed is F5; the disease is hyperhomocysteinemia.