Additional evidence for SERPING1 involving AMD includes: 1) SERPING1 gene encoding C1INH plays an important role in complement pathways, which have been confirmed to participate in the pathogenesis of AMD; and 2) SERPING1 was expressed in both retinal and RPE-choroid layers in RT–PCR and immunofluorescence studies [25,29]. Here, SERPING1 is linked to age-related macular degeneration.