Although genes in complement pathways, including CFH, C2/BF, and C3 [2,8–17] and chr.10q26 (LOC387715/HTRA1) [18–24], have been identified as related to AMD, these loci could not explain all genetic contributions to AMD, suggesting that additional genetic variants related to AMD have not yet been found. Here, C2 is linked to age-related macular degeneration.