The collective up-regulation of citrate synthase (CS) and various lipogenic proteins [e.g. isopentenyl-diphosphate delta isomerase 1 (IDI1), fatty acid binding protein 1 (FABP1), MAC30 protein (TMEM97), and fatty acid synthase (FASN)] 24 h after infection suggests that TCA cycle activity is coupled with the generation of cytosolic citrate for fatty acid synthesis, producing lipid species to support the viral life cycle (Fig. 2, Supplementary Table S2). The gene discussed is TMEM97; the disease is infection.