To assess precisely the involvement of Dectin-1 in the development of gastrointestinal candidiasis and in the antifungal effect of PPARγ ligands, we studied the susceptibility to Candida infection of macrophage-specific Dectin-1 deficient (Cre Tg) mice treated or not with rosiglitazone. The gene discussed is CLEC7A; the disease is candidiasis.