It has also been previously noted that infection with H3N2 viruses is somewhat protective against reinfection with H1N1 viruses and vice versa [43] This less specific immunological experience coupled with a non-H1N1 OAS response appears to have produced a susceptibility to novel H1N1 intermediate between the two age groups with a direct OAS response to H1N1 viruses. This evidence concerns the gene SMOC1 and infection.