In the present study, retinal degeneration that was characterized by the disappearance of the outer nuclear layer and the photoreceptor layer in both the peripheral and central retina was detected in p53−/− mice, p53+/− mice, and p53+/+ mice 7 days after a single i.p. injection of 60 mg/kg MNU. Here, TP53 is linked to retinal degeneration.