PLA2G10 and asthma: Because PLA2 is an enzyme that catalyses the first rate-limiting step leading to eicosanoids, and specifically sPLA2-X has recently been identified as a potential mediator of AHR in a murine model of asthma and in human subjects with asthma, these findings may reveal a novel mechanism that functionally serves to amplify airway inflammation through the generation of inflammatory eicosanoids known to be increased in the EIB phenotype.