More recently antisera from a number of HIV-infected individuals, usually obtained late in the course of infection, have been described that are broadly neutralizing [31], [32], [33] and current studies are finding that the neutralizing Abs in these sera are directed against a variety of epitopes on gp120, including some in the CD4 binding region and in the co-receptor binding regions [31], [32], [33]. Here, ITIH4 is linked to infection.