Studies have recently revealed the existence of a negative-feedback loop by which mTORC1 inhibition leads to upregulation of Akt (Manning, 2004; O’Reilly et al, 2006) and/or ERK/MAPK pathway (Carracedo et al, 2008), activating proliferative and anti-apoptotic signals in certain cancer types. Here, AKT1 is linked to cancer.