Indeed we reported that inositol 1,3,4,5,6-pentakisphosphate (InsP5) specifically blocks Akt activation and possesses pro-apoptotic (Razzini et al, 2000; Piccolo et al, 2004), anti-angiogenic and anti-tumour activity in vivo (Maffucci et al, 2005). The gene discussed is AKT1; the disease is neoplasm.