Accumulation of PtdIns(3,4,5)P3 either due to gain of function of PI3K activity (Vivanco and Sawyers, 2002; Vogt et al, 2007) or loss of the enzyme phosphatase and tensin homolog deleted on chromosome 10 (PTEN), which specifically dephosphorylates PtdIns(3,4,5)P3 (Maehama and Dixon, 1999), has been detected in almost 50% of all tumour types (Carracedo and Pandolfi, 2008). This evidence concerns the gene PTEN and neoplasm.