EWSR1 and neoplasm: As shown in Figure 8, all six mice injected with ZHBTc4 cells expressing EWS-Oct-4B developed large tumours within a relatively short latent period, showing that EWS-Oct-4B functions as an oncogene, at least as efficiently as EWS-Oct-4 (Lee et al, 2007) or Oct-4 (Gidekel et al, 2003).