For patients whose tumours expressed either a high uPA-T or a high PAI-1-T antigen level, we detected a significantly, nearly three-fold increased risk of tumour-related death (RR=2.9, 95% CI=1.1–7.7, P=0.032; and RR=2.6, 95% CI=1.1–6.0, P=0.029, respectively) compared with those patients who displayed low uPA-T or PAI-1-T values in their tumours, respectively (Table 3). This evidence concerns the gene PLAU and neoplasm.