High levels of uPA-T, uPAR-T and PAI-1-T antigen were significantly associated with histological subtype (P<0.001, P<0.001 and P=0.006, respectively), with tumour grade (P<0.001, P<0.001 and P=0.001, respectively), and with tumour stage (P<0.001, P<0.001 and P=0.006, respectively). This evidence concerns the gene SERPINE1 and neoplasm.