In multivariate Cox's regression analysis, the subgroup of patients with high uPA-T/uPAR-T, high uPA-T/PAI-1-T or high uPAR-T/PAI-1-T antigen levels showed the worst OS with RR values of 3.3 (95% CI=1.2–9.6, P=0.026) 3.6 (95% CI=1.2–10.4, P=0.019) or 3.2 (95% CI=1.1–9.4, P=0.034), respectively, compared with patients having tumours with low values for both markers (Table 4). The gene discussed is SERPINE1; the disease is neoplasm.