TLR4 and tuberculosis: For example in the mouse model of tuberculosis, 38 kDa glycolipid and PIM6 are sensed through TLR4 and have been found to trigger a protective type Th1 cytokine response in the lungs during Mycobacterium tuberculosis (M.tb) infection [15,16], whereas TLR2 ligation by mycobacterial liparabinomannan modulates inflammatory responses in mouse macrophages [17].