When both sTNFR-II and IL-8 were combined together, all HCC cases 100% had either sTNFR-II ≥ 398 pg/ml or IL-8 < 290 pg/ml (p = 0.000) and 21/30 (70%) HCC had sTNFR-II ≥ 398 pg/ml and IL-8 < 290 pg/ml compared to none of PNALT cases (p = 0.000). The gene discussed is CXCL8; the disease is hepatocellular carcinoma.