NFKB1 and carcinoma: To assess whether EBNA1 influenced NF-κB activity we initially performed luciferase reporter assays in a range of carcinoma cell lines using a synthetic NF-κB reporter and found that NF-κB activity in Ad/AH, AGS and Hone1 cells stably expressing levels of EBNA1 comparable to those found in EBV infection was inhibited by 8, 5 and 2.6 fold, respectively (Fig. 1).