As visualized with Kaplan-Meier plots (Figure 3B), the patients with early stage breast cancers with a high expression level of the breast fibroblast derived IGF-I signature had a significantly higher risk of developing metastasis than the patients with a low expression level (P = 6.75e-05, 52% versus 73% after 10 years, hazard ratio (HR): 2.24, 95% confidence interval [CI]: 1.5-3.4; top panel). This evidence concerns the gene IGF1 and breast cancer.