IGF-I stimulation increased the mRNA expression level of numerous genes (such as BMP7, ID1, ID3, SRF and VEGF) that play a role in tumour biology as well as genes with ontologies assigned to protein metabolism (RPS6KA4, PSMC4, MAPK6, LMAN2L, RPL8, EIF5 and CEBPB), responses to a protein stimulus and to unfolded protein (HSP90AA1, HSPE1, HSPA1A, DNAJA1, HSPA4, HSP90AB1, HSPH1, and DNAJB1). This evidence concerns the gene RPS6KA4 and neoplasm.