TNC and neoplasm: The gene expression changes induced by IGF-I in fibroblasts contained several soluble factors, such as POSTN, which was reported to be involved in bone metastasis formation and angiogenesis [56,57], TNC, which enhances tumour cell proliferation [58], as well as LOXL1, a member of lysyl oxidase family, similar to LOXL2, that might act on or in the vicinity of epithelial cells during tissue remodelling.