PRNP and Creutzfeldt Jacob disease: Prions are agents that are capable of inducing abnormal folding of the cellular prion protein through a mechanism that remains a matter of debate.3 They are the purported unconventional causative agents of this family of diseases that includes classic Creutzfeldt-Jakob disease (CJD) and variant CJD (vCJD) in humans [1], [2], [4].