Oculocutaneous albinism (OCA) is the most common inherited disorder of general hypopigmentation, with an estimated frequency of 1: 20,000, in most populations.[1] There are several types of albinism.[2] Tyrosinase-related OCA (OCA1), one of the two most common types of albinism, is produced by loss of function of the melanocytic enzyme tyrosinase, resulting from mutations of the tyrosinase gene. The gene discussed is TYR; the disease is albinism.