The protein circulates at concentrations proportional to body fat and decreases body weight by inhibiting food intake and inducing thermogenesis.[6] Recently, leptin has been reported to stimulate the proliferation of various cell types and is considered to be a new growth factor.[7,8] Leptin exerts a number of regulatory functions; most of them are poorly understood.[9] Plasma leptin displays a strong association with cardiovascular risk factors, including obesity, insulin resistance, hypertension, dyslipidemia, hyperuricemia, inflammatory markers.[10,11]. The gene discussed is LEP; the disease is Insulin resistance.