EIF4E and acute myeloid leukemia: Interestingly, transduction of primary leukemia specimens (M4/M5 AML) with the inhibitor of NFκB activity, IκB-SR, leads to a substantial re-organization of eIF4E, reducing the amount of eIF4E found in the nuclear fraction and increasing the amount in the cytoplasm, and reorganization of the remaining eIF4E nuclear bodies into structures which are morphologically indistinguishable from normal cells [37, 93].