On the other hand, the aberrant expression of chemokines in tumors induces immunosuppression and favors tumor growth as shown in hepatocellular carcinoma, where high levels of CXCL9 and CXL10 have been associated with inhibition of CXCR3 expression by CD8+ T limphocytes, reduction of T-cell tumor infiltration and cytotoxic functions and tumor growth [48]. This evidence concerns the gene CXCL9 and neoplasm.