For example, in melanoma, while chemokines contribute to the recruitment of CD8+ T lymphocytes expressing CXCR3 that infiltrate the tumor leading to the improvement of patient survival [22], the lack of critical chemokines (CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL10) in melanoma metastases may block the migration of activated T cells, which in turn could limit the effectiveness of antitumor immunity [47]. This evidence concerns the gene CCL4 and melanoma.