STAT3 and cancer: The molecular pathways activated in tumor cells that control cancer-related immunity include transcription factors, such as nuclear factor-κB (NF-κB), hypoxia inducible factor α (HIF1α), and signal transducer and activator of transcription 3 (STAT3), which, in turn, control the production of other chemokines and inflammatory mediators (prostaglandins, cytokines).