In addition, downregulation of CXCR4 and CXCL12 and inhibition of chemotaxis and chemoinvasion in breast and ovarian cancer cells toward CXCL12 are among of the biological effects of genistein [93] likely through the inhibition of the estrogen dependent CXCL12 mRNA synthesis. The gene discussed is CXCR4; the disease is ovarian carcinoma.