In particular, this notion is further supported by the different mechanisms resulting from CXCR4 inhibition: (a) the reversal of stromal cell interactions responsible of tumor cell survival; (b) the blockade of proangiogenic activity of CXCL12 and the reduction of the dissemination and migration ability of tumor cells; (c) the blockade of tumor growth through autocrine/paracrine signaling mediated by CXCL12/CXCR4 interaction; (d) the mobilization of tumor cells from tissues to increase their sensitivity to conventional chemoterapeutic agents. Here, CXCL12 is linked to neoplasm.