Some human data on PPAR-α agonist effects are available from fibrate clinical trials and population case–control studies of site-specific cancer (Bezafibrate Infarction Prevention Study Group 1992, 2000; Canner et al. 1986; Committee of Principal Investigators 1978, 1980, 1984; Coronary Drug Research Group 1975, 1977; De Faire et al. 1995; Diabetes Atherosclerosis Intervention Study Investigators 2001; Freeman et al. 2006; Frick et al. 1987, 1997; Huttunen et al. 1994; Keech et al. 2005, 2006; Meade 2001; Rubins et al. 1993, 1999; Tenkanen et al. 2006). Here, PPARA is linked to cancer.