Indeed, with regard to the hepatic, testicular, and pancreatic cancers associated with phthalate exposures, a report of the National Research Council (2008b) concluded that “there is evidence that these cancer types may be mediated by mechanisms independent of PPARα.” Therefore, the adequacy of the scientific basis for the conclusion that PPAR-α agonists pose no carcinogenic risk to humans requires reexamination. Here, PPARA is linked to familial pancreatic carcinoma.