Relativelylittle is known about the role the shelterin components play in tumorigenesis.TRF1, TRF2 and TIN2 have been found up-regulated occasionally during in gastriccarcinomas and during hepatocarcinogenesis [22,23].Mutations in TIN2 have been demonstrated to lead to abnormally short telomeres,and to be associated with dyskeratosis congenita and ataxia-pancytopenia,diseases associated with an increased cancer disposition [24-26]. The gene discussed is TINF2; the disease is Ataxia - pancytopenia.