TP53 and ovarian carcinoma: Therefore, to develop a mouse model of Brca1- and p53-associated inherited EOC, we used two approaches for inactivation or mutation of p53. First, we predicted that using a strategy for tissue-restricted conditional inactivation of p53LoxP/LoxP in combination with Brca1LoxP/LoxP in the OSE would result in predisposition for the development of ovarian carcinomas.