TP53 and infection: Based on the successful demonstration of efficient, tissue-restricted infection with the Ad5-CMV-ntLacZ and Ad5-CMV-Cre viruses, we commenced with intrabursal Ad5-CMV-Cre injection of the following groups of mice: 1) Brca1LoxP/LoxP, 2) p53LoxP/LoxP, 3) Brca1LoxP/LoxP;p53LoxP/LoxP, 4) Brca1LoxP/LoxP;p53+/515A and 5) Brca1LoxP/LoxP;p53LoxP/515A.