BRCA1 and ovarian neoplasm: To determine whether inactivation of both Brca1 and p53 in the OSE can cooperate to induce ovarian tumorigenesis, we evaluated ovarian tumor formation in Brca1LoxP/LoxP;p53LoxP/LoxP, Brca1LoxP/LoxP;p53+/515A and Brca1LoxP/LoxP;p53LoxP/515A mice following intrabursal injection of Ad5-CMV-Cre.