We need to consider that the A218C SNP is not the sole determinant of the functionality of the TPH1 gene, because it is in LD with putative functional SNPs in the promoter region, such as A-1067G and G-347T,16 as well as other intron SNPs.36 As our results show that the A218C SNP alone is not a major genetic risk factor for eating disorders, the analysis of the effect of the haplotypes and, more importantly, of the functionality of each haplotype, on the expression of the THP1 gene is required to clarify the involvement of the THP1 gene in eating disorders. This evidence concerns the gene GLI2 and eating disorder.