In the present study, we also did not find a sig-nificant association between GNB 825C/T SNP and olanzapine-induced weight gain, which was consistent with the previous Asian studies.40,41 It is possible that there are ethnic differences in the relationship between GNB3 825C/T SNP and obesity; however, recently, Ujike et al.42 reported the 825T allele of GNB3 was significantly associated with olanzapine-induced weight gain in 164 Japanese schizophrenic patients. The gene discussed is GNB3; the disease is obesity due to melanocortin 4 receptor deficiency.