Bipolar disorder is known to be affected by genetic factors.1-3 Although it is not a classical neurodegenerative disease, bipolar disorder has been recently reported to be associated with a neurodegenerative pathophysiology.4 Moreover, cell-life promoting events are reasonably responsible for neuronal plasticity and resilience, which have been recognized as relevant factors in the development of bipolar disorder.5 Therefore, the dysbindin seems to be a good candidate as it is associated with both intracellular trafficking and signal transduction.6,7. This evidence concerns the gene DTNBP1 and bipolar disorder.