More intriguingly, 12 (57%) (HHEX, HNF1B, IGF2BP2, IRS1, KCNJ11, KCNQ1, NOTCH2, PPARG, TCF7L2, THADA, TSPAN8 and WFS1) out of 21 genes located in vicinity of known 26 T2DM or related traits associated SNPs showed different expression in tissues of individuals with or without T2DM or animal models thereof. This evidence concerns the gene IRS1 and type 2 diabetes mellitus.