Thus, in transgenic fat-1 mouse there will be significant alterations in the concentrations and expression of cytokines, pro-inflammatory eicosanoids, insulin, neurotransmitters, PLA2, sphingosine kinase, caspases, farnesoid X receptor, PPARs, SREBPs, HMG-CoA reductase, transforming growth factor, cytokeratins, and nitric oxide synthase ([15,47-50] and see Table 4) that accounts for the decreased incidence of cardiovascular and neurological and psychiatric disorders (see Figure 3). This evidence concerns the gene HMGCR and psychiatric disorder.